BDBM50387569 CHEMBL2057714

SMILES C1CN2CCC1C21CCN(C1)c1cccnc1

InChI Key InChIKey=LIWBYJGLHCGRCM-UHFFFAOYSA-N

Data  3 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50387569   

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50387569(CHEMBL2057714)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-epibatidine from human nAChR alpha4beta2 expressed in human SH-EP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50387569(CHEMBL2057714)
Affinity DataKi:  560nMAssay Description:Binding affinity to human ganglionic nAChR alpha3beta4 expressed in human SHSY-5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50387569(CHEMBL2057714)
Affinity DataKi:  7.60E+3nMAssay Description:Binding affinity to human nAChR alpha7 expressed in HEK cells coexpressing RIC3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50387569(CHEMBL2057714)
Affinity DataEC50:  2.60E+3nMAssay Description:Antagonist activity at human ganglionic nAChR alpha3beta4 expressed in human SHSY-5Y cells assessed as calcium flux by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed