Found 5 hits for monomerid = 50388398 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dehydrosqualene synthase
(Staphylococcus aureus) | BDBM50388398
 (CHEMBL561057 | SQ-109)Show InChI InChI=1S/C22H38N2/c1-16(2)5-4-6-17(3)7-8-23-9-10-24-22-20-12-18-11-19(14-20)15-21(22)13-18/h5,7,18-24H,4,6,8-15H2,1-3H3/b17-7+ | PDB MMDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank GoogleScholar
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CHEMBL DrugBank PC cid PC sid PDB UniChem
| PDB Article PubMed
| 360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Urbana-Champaign
Curated by ChEMBL
| Assay Description Inhibition of Staphylococcus aureus ATCC 27659 dehydrosqualene synthase expressed in Escherichia coli BL21(DE3) after 30 mins by spectrophotometric a... |
J Med Chem 55: 4367-72 (2012)
Article DOI: 10.1021/jm300208p BindingDB Entry DOI: 10.7270/Q2Z320QH |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Squalene synthetase
(Homo sapiens (Human)) | BDBM50388398
 (CHEMBL561057 | SQ-109)Show InChI InChI=1S/C22H38N2/c1-16(2)5-4-6-17(3)7-8-23-9-10-24-22-20-12-18-11-19(14-20)15-21(22)13-18/h5,7,18-24H,4,6,8-15H2,1-3H3/b17-7+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar
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CHEMBL DrugBank PC cid PC sid PDB UniChem
| Article PubMed
| 740 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Urbana-Champaign
Curated by ChEMBL
| Assay Description Inhibition of human squalene synthase |
J Med Chem 55: 4367-72 (2012)
Article DOI: 10.1021/jm300208p BindingDB Entry DOI: 10.7270/Q2Z320QH |
More data for this Ligand-Target Pair | |
Dehydrosqualene synthase
(Staphylococcus aureus) | BDBM50388398
 (CHEMBL561057 | SQ-109)Show InChI InChI=1S/C22H38N2/c1-16(2)5-4-6-17(3)7-8-23-9-10-24-22-20-12-18-11-19(14-20)15-21(22)13-18/h5,7,18-24H,4,6,8-15H2,1-3H3/b17-7+ | PDB MMDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank GoogleScholar
| Purchase
CHEMBL DrugBank PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Urbana-Champaign
Curated by ChEMBL
| Assay Description Inhibition of Staphylococcus aureus CrtM |
J Med Chem 57: 3126-39 (2014)
Article DOI: 10.1021/jm500131s BindingDB Entry DOI: 10.7270/Q27P90ZN |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Geranylgeranyl Diphosphate Synthase (GGPPS)
(Homo sapiens (Human)) | BDBM50388398
 (CHEMBL561057 | SQ-109)Show InChI InChI=1S/C22H38N2/c1-16(2)5-4-6-17(3)7-8-23-9-10-24-22-20-12-18-11-19(14-20)15-21(22)13-18/h5,7,18-24H,4,6,8-15H2,1-3H3/b17-7+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar
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CHEMBL DrugBank PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Urbana-Champaign
Curated by ChEMBL
| Assay Description Inhibition of human geranylgeranyl diphosphate synthase |
J Med Chem 57: 3126-39 (2014)
Article DOI: 10.1021/jm500131s BindingDB Entry DOI: 10.7270/Q27P90ZN |
More data for this Ligand-Target Pair | |
Squalene synthetase
(Homo sapiens (Human)) | BDBM50388398
 (CHEMBL561057 | SQ-109)Show InChI InChI=1S/C22H38N2/c1-16(2)5-4-6-17(3)7-8-23-9-10-24-22-20-12-18-11-19(14-20)15-21(22)13-18/h5,7,18-24H,4,6,8-15H2,1-3H3/b17-7+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar
| Purchase
CHEMBL DrugBank PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Urbana-Champaign
Curated by ChEMBL
| Assay Description Inhibition of human SQS |
J Med Chem 57: 3126-39 (2014)
Article DOI: 10.1021/jm500131s BindingDB Entry DOI: 10.7270/Q27P90ZN |
More data for this Ligand-Target Pair | |