BDBM50389241 CHEMBL1990583

SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12

InChI Key InChIKey=DASFSPDIWCMVRW-UHFFFAOYSA-N

Data  22 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50389241   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Chk1 in presence of 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50:  2.09E+3nMAssay Description:Inhibition of EGFR in presence of 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: <3nMAssay Description:Inhibition of Aurora B kinase in presence of 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: <3nMAssay Description:Inhibition of Aurora A kinase in presence of 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50:  9nMAssay Description:Inhibition of Aurora B kinase by HTRF analysis in presence of 1 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Src in presence of 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50:  1.87E+3nMAssay Description:Inhibition of TrkA in presence of 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50:  1.18E+3nMAssay Description:Inhibition of KDR in presence of 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of Flt3 in presence of 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50:  566nMAssay Description:Inhibition of lck in presence of 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50:  340nMAssay Description:Inhibition of Irak4 in presence of 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50:  296nMAssay Description:Inhibition of Erk2 in presence of 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Rock2 in presence of 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of c-Met in presence of 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Jnk1 in presence of 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Jak2 in presence of 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IGF1R in presence of 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type IV(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Camk4 in presence of 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Alk1 in presence of 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50:  8.14E+3nMAssay Description:Inhibition of Jak3 in presence of 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50:  5.34E+3nMAssay Description:Inhibition of Gsk3alpha in presence of 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50389241(CHEMBL1990583)
Affinity DataIC50: <3nMAssay Description:Inhibition of Plk4 in presence of 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed