BDBM50389803 AZD7762::CHEMBL2041933
SMILES NC(=O)Nc1cc(sc1C(=O)N[C@H]1CCCNC1)-c1cccc(F)c1
InChI Key InChIKey=IAYGCINLNONXHY-LBPRGKRZSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50389803
TargetSerine/threonine-protein kinase/endoribonuclease IRE1 [547-977](Homo sapiens (Human))
University Of Washington
University Of Washington
Affinity DataIC50: 650nMpH: 7.5Assay Description:Inhibitors (initial concentration 10 or 60 μM, three-fold serial dilutions) were incubated with IRE1α* in cleavage buffer (20 mM HEPES at p...More data for this Ligand-Target Pair
Affinity DataEC50: 280nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as check point abrogationMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of campothecin induced check pointMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:Inhibition of Chk1 (unknown origin) by luminescent ADP-Glo assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of CHK1 (unknown origin) using Cdc25 peptide as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant CHK1 expressed in insect cells using biotinylaminohexanoyl-KKVSRSGLYRSPMPENLNRPR as substrate after 2 hrs by scintill...More data for this Ligand-Target Pair