BDBM50389822 CHEMBL2070697

SMILES NC(=O)Nc1cc(sc1C(=O)N[C@H]1CCCNC1)-c1ccccc1

InChI Key InChIKey=KZWJNCUHHASMNZ-LBPRGKRZSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50389822   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50389822(CHEMBL2070697)
Affinity DataEC50:  590nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as check point abrogationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50389822(CHEMBL2070697)
Affinity DataEC50:  20nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of campothecin induced check pointMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50389822(CHEMBL2070697)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant CHK1 expressed in insect cells using biotinylaminohexanoyl-KKVSRSGLYRSPMPENLNRPR as substrate after 2 hrs by scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed