BDBM50390258 CHEMBL2070411

SMILES CN1CCN(CCCOc2ccc(cc2)N2C(=S)S\C(=C/c3ccc(Oc4ccccc4C(N)=O)cc3)C2=O)CC1

InChI Key InChIKey=KLRBTXKTXZJLEQ-HFTWOUSFSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50390258   

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50390258(CHEMBL2070411)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibition of IKKbeta using 5FAM-GRHDSGLDSMK-NH2 as substrate incubated for 10 mins prior to substrate addition by IMAP-TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Mus musculus)
Korea University

Curated by ChEMBL
LigandPNGBDBM50390258(CHEMBL2070411)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of IKKbeta in mouse CIA model spelonocytes assessed as inhibition of TNFalpha production after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed