BDBM50392148 CHEMBL2152778

SMILES COc1ccc2CCc3cc(Nc4ccc(F)cc4F)ccc3C(=O)c2c1

InChI Key InChIKey=CPDXPKUSKNZCQM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50392148   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50392148(CHEMBL2152778)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of p38alpha-dependent TNFalpha production in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50392148(CHEMBL2152778)
Affinity DataIC50:  44nMAssay Description:Competitive inhibition of p38alpha MAP kinase (unknown origin) in presence of 100 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50392148(CHEMBL2152778)
Affinity DataIC50:  1.65E+3nMAssay Description:Inhibition of p38alpha MAP kinase in human whole blood assessed as inhibition of LPS-induced TNFalpha release by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM50392148(CHEMBL2152778)
Affinity DataIC50:  20nMAssay Description:Inhibition of p38alpha by immunosorbent based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed