BDBM50392953 CHEMBL2152353

SMILES CC[C@H](C[C@H](O)[C@@H](N)CN1CC(=O)N(CC1(C)C)c1ccccc1Cl)C(=O)NC1C2CC3CC1CC(O)(C3)C2

InChI Key InChIKey=MGQQKSSUXHKDSK-DLUCIBEJSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50392953   

TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50392953(CHEMBL2152353)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50392953(CHEMBL2152353)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human recombinant renin compound treated for 10 mins before substrate addition measured after 90 mins by fluorescence methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392953(CHEMBL2152353)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Macaca fascicularis)
TBA

Curated by ChEMBL
LigandPNGBDBM50392953(CHEMBL2152353)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of cynomolgus monkey plasma renin activity after 60 mins by competitive RIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392953(CHEMBL2152353)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50392953(CHEMBL2152353)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human plasma renin activity after 60 mins by competitive RIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed