BDBM50393456 CHEMBL2159690

SMILES CCNC(=O)OCC[C@@H]1OCC[C@@]2([C@H]1COc1c(F)ccc(F)c21)S(=O)(=O)c1ccc(Cl)cc1

InChI Key InChIKey=CBBFOFOYZAQDFL-NVVBAYIOSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50393456   

TargetPresenilin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50393456(CHEMBL2159690)
Affinity DataIC50:  48nMAssay Description:Inhibition of PS1 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-40 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50393456(CHEMBL2159690)
Affinity DataIC50:  20nMAssay Description:Inhibition of PS2 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-42 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50393456(CHEMBL2159690)
Affinity DataIC50:  24nMAssay Description:Inhibition of PS1 gamma-secretase assessed as reduction of amyloid beta-40 production by membrane based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed