BDBM50398790 CHEMBL2180072

SMILES C[C@@H](N1CC(C1)Oc1ccccc1)c1nc2n(ncc2c(=O)[nH]1)C1CCCC1

InChI Key InChIKey=KKFKLLKJGDFZBA-CQSZACIVSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50398790   

LigandPNGBDBM50398790(CHEMBL2180072)
Affinity DataIC50:  116nMAssay Description:Inhibition of PDE1CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398790(CHEMBL2180072)
Affinity DataIC50:  45nMAssay Description:Inhibition of PDE9A using [3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
LigandPNGBDBM50398790(CHEMBL2180072)
Affinity DataIC50:  297nMAssay Description:Inhibition of PDE1CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50398790(CHEMBL2180072)
Affinity DataIC50:  11nMAssay Description:Inhibition of PDE9A using [3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair