BDBM50400179 2,3‐dihydroxy‐6‐(phenylsulfanyl)anthracene‐9,10‐ dione (Ligand 4)::CHEMBL2180319
SMILES Oc1cc2C(=O)c3ccc(Sc4ccccc4)cc3C(=O)c2cc1O
InChI Key InChIKey=JPNPTHYSPUJGKU-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50400179
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Dalian University Of Technology
Curated by ChEMBL
Dalian University Of Technology
Curated by ChEMBL
Affinity DataKi: 53nMAssay Description:Binding affinity to Mcl-1 after 30 mins by florescence polarization assayMore data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Dalian University Of Technology
Curated by ChEMBL
Dalian University Of Technology
Curated by ChEMBL
Affinity DataKi: 71nMAssay Description:Binding affinity to Bcl-2 after 30 mins by florescence polarization assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [172-327](Homo sapiens (Human))
Dalian University Of Technology
Dalian University Of Technology
Affinity DataKd: 1.47E+3nMpH: 8.0 T: 2°CAssay Description:ITC experiments were carried out using iTC200 (Microcal LLC, Northampton, MA, USA) with each of the compounds 1-6 and Mcl-1 protein. The heat of rea...More data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 1 hit for monomerid = 50400179
CellInduced myeloid leukemia cell differentiation protein Mcl-1 (aa 172-327)(Homo sapiens (Human))
Dalian University Of Technology
Dalian University Of Technology
ITC DataΔG°: -8.00kcal/mole −TΔS°: -2.79kcal/mole ΔH°: -5.21kcal/mole logk: 7.40E+5
pH: 8.0 T: 25.00°C
pH: 8.0 T: 25.00°C