BDBM50403547 ATROPEN::ATROPINE
SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c1ccccc1
InChI Key InChIKey=RKUNBYITZUJHSG-SPUOUPEWSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 69 hits for monomerid = 50403547
Affinity DataKi: 0.120nMAssay Description:Ability to displace [3H]N-methylscopolamine (NMS) from M3 receptor in rat submaxillary gland homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor M1 by displacement of [3H]pirenzepine in bovine striatumMore data for this Ligand-Target Pair
Affinity DataKi: 0.260nMAssay Description:Ability to displace [3H]pirenzepine (PZ) from M1 receptor in rat cortex homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 0.260nMAssay Description:Displacement of [3H]pirenzepine from muscarinic acetylcholine receptor M1 in rat cortex homogenatesMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 0.300nMAssay Description:The compound was tested for inhibition of [3H]NMS binding against muscarinic acetylcholine receptor in rat brainMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Displacement of [3H]pirenzepine from muscarinic M1 receptorMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Homo sapiens (Human))
Uppsala University
Curated by ChEMBL
Uppsala University
Curated by ChEMBL
Affinity DataKi: 0.320nMAssay Description:Ability of compound to displace (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in cerebral cortex from Guinea...More data for this Ligand-Target Pair
Affinity DataKi: 0.329nMAssay Description:Inhibition of [3H]QNB binding to CHO cells bearing transfected muscarinic acetylcholine receptor M3More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 0.337nMAssay Description:Inhibition of [3H]QNB binding against muscarinic acetylcholine receptor in rat brain.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 0.337nMAssay Description:Inhibition of [3H]QNB binding to muscarinic acetylcholine receptor of rat heart membrane preparation.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 0.344nMAssay Description:muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
Affinity DataKi: 0.350nMAssay Description:Compound was evaluated for the binding affinity by displacing [3H]oxotremorine from mouse cerebral cortex tissue.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Mus musculus)
University Of South Carolina
Curated by ChEMBL
University Of South Carolina
Curated by ChEMBL
Affinity DataKi: 0.350nMAssay Description:Ability of the compound to displace [3H]-methylscopolamine ([3H]-NMS) from mouse cerebral cortexMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
University Of South Florida
Curated by ChEMBL
University Of South Florida
Curated by ChEMBL
Affinity DataKi: 0.400nMAssay Description:Displacement of [3H]QNB from muscarinic acetylcholine M5 receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 0.450nMAssay Description:Displacement of [3H]QNB from rat ileum Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 0.459nMAssay Description:Inhibition of [3H]- Oxo-M binding to muscarinic acetylcholine receptor of rat brain membrane preparationsMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 0.459nMAssay Description:Inhibition of [3H]OXO-M binding against muscarinic acetylcholine receptor in rat brain membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Evaluated for the phosphatidyl inositol turnover at Muscarinic acetylcholine receptor M1 in rat cortexMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(RAT)
Dvanderbilt Program In Drug Discovery
Curated by ChEMBL
Dvanderbilt Program In Drug Discovery
Curated by ChEMBL
Affinity DataKi: 0.520nMAssay Description:Displacement of [3H]NMS from rat recombinant muscarinic M4 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(RAT)
Dvanderbilt Program In Drug Discovery
Curated by ChEMBL
Dvanderbilt Program In Drug Discovery
Curated by ChEMBL
Affinity DataKi: 0.520nMAssay Description:Displacement of [3H]NMS from rat recombinant muscarinic M4 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(RAT)
Dvanderbilt Program In Drug Discovery
Curated by ChEMBL
Dvanderbilt Program In Drug Discovery
Curated by ChEMBL
Affinity DataKi: 0.560nMAssay Description:Displacement of [3H]NMS from rat muscarinic M4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Compound was evaluated for the binding affinity by displacing [3H]oxotremorine from mouse cerebral cortex tissue.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Mus musculus)
University Of South Carolina
Curated by ChEMBL
University Of South Carolina
Curated by ChEMBL
Affinity DataKi: 0.700nMAssay Description:Ability of the compound to displace [3H]-methylscopolamine ([3H]-NMS) from mouse cerebral cortexMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumMore data for this Ligand-Target Pair
Affinity DataKi: 0.760nMAssay Description:Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesMore data for this Ligand-Target Pair
Affinity DataKi: 0.760nMAssay Description:Ability to displace [3H](-)-quinuclidinyl bezilate(QNB) from M2 receptor in rat heart homogenateMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Homo sapiens (Human))
Uppsala University
Curated by ChEMBL
Uppsala University
Curated by ChEMBL
Affinity DataKi: 0.850nMAssay Description:Ability of compound to displace (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in the parotid gland from Guin...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(RAT)
Dvanderbilt Program In Drug Discovery
Curated by ChEMBL
Dvanderbilt Program In Drug Discovery
Curated by ChEMBL
Affinity DataKi: 0.860nMAssay Description:Displacement of [3H]NMS from rat recombinant muscarinic M5 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Homo sapiens (Human))
Uppsala University
Curated by ChEMBL
Uppsala University
Curated by ChEMBL
Affinity DataKi: 0.890nMAssay Description:Ability of compound to displace (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in the heart from Guinea Pig.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 0.900nMAssay Description:Binding affinity against Muscarinic acetylcholine receptors using [3H]oxotremorine-M as radioligand in rat cortexMore data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Displacement of [3H]-4-DAMP from human muscarinic M3 receptor expressed in BHK-21 cellsMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 0.912nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plat...More data for this Ligand-Target Pair
Affinity DataKi: 0.922nMAssay Description:Displacement of [3H] N-methylscopolamine from human muscarinic M1 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Homo sapiens (Human))
Uppsala University
Curated by ChEMBL
Uppsala University
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Inhibit the binding of [N-mnethyl-3H]-scopolamine [3H]-NMS) to Muscarinic acetylcholine receptor of human IRM-30 neuroblastoma cellsMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
University Of South Florida
Curated by ChEMBL
University Of South Florida
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Displacement of [3H]-4-DAMP from human muscarinic M5 receptor expressed in BHK-21 cellsMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Binding affinity towards muscarinic m2 receptorMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Walter Reed Army Institute Of Research
Curated by ChEMBL
Walter Reed Army Institute Of Research
Curated by ChEMBL
Affinity DataKi: 1.39nMAssay Description:Displacement of [3H] N-methylscopolamine from human muscarinic M4 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Displacement of [3H]NMS from rat muscarinic M1 receptor expressed in CHO cells after 3 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Displacement of [3H]NMS from rat muscarinic M1 receptor expressed in CHO cells after 3 hrsMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 1.44nMAssay Description:Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
University Of South Florida
Curated by ChEMBL
University Of South Florida
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Displacement of [3H]NMS from human muscarinic acetylcholine receptor subtype 5 expressed in CHO cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Homo sapiens (Human))
Uppsala University
Curated by ChEMBL
Uppsala University
Curated by ChEMBL
Affinity DataKi: 1.60nMAssay Description:Affinity for Muscarinic acetylcholine receptors in urinary bladder from Guinea Pig by (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB displacement.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(RAT)
Dvanderbilt Program In Drug Discovery
Curated by ChEMBL
Dvanderbilt Program In Drug Discovery
Curated by ChEMBL
Affinity DataKi: 1.80nMAssay Description:Displacement of [3H]NMS from rat muscarinic M5 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 1.90nMAssay Description:Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Binding affinity towards muscarinic m1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2.18nMAssay Description:Displacement of [3H] N-methylscopolamine from human muscarinic M3 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 2.40nMAssay Description:Inhibition of [3H]NMS binding to cerebral cortex membranes which contain predominantly the Muscarinic acetylcholine receptor M1 subtypesMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 2.5nMAssay Description:Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)pipe...More data for this Ligand-Target Pair
Affinity DataKi: 2.51nMAssay Description:Binding affinity to Muscarinic acetylcholine receptor M3 by measuring its ability to displace [3H]N-methylscopolamine binding in rat submandibulary g...More data for this Ligand-Target Pair