BDBM50405043 1-(4-(Benzyloxy)phenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride (B2-01)::CHEMBL7191

SMILES CC1(C)N=C(N)N=C(N)N1c1ccc(OCc2ccccc2)cc1

InChI Key InChIKey=HUTXUOTUXFTILM-UHFFFAOYSA-N

Data  3 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50405043   

TargetDihydrofolate reductase(Gallus gallus (Chicken))
TBA

Curated by ChEMBL
LigandPNGBDBM50405043(1-(4-(Benzyloxy)phenyl)-6,6-dimethyl-1,6-dihydro-1...)
Affinity DataKi:  30nMAssay Description:Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405043(1-(4-(Benzyloxy)phenyl)-6,6-dimethyl-1,6-dihydro-1...)
Affinity DataKi:  117nMAssay Description:Inhibitory activity against human lymphoblastoid cell (WIL2) dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50405043(1-(4-(Benzyloxy)phenyl)-6,6-dimethyl-1,6-dihydro-1...)
Affinity DataKi:  6.46E+3nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Institute Of Chemical Technology

LigandPNGBDBM50405043(1-(4-(Benzyloxy)phenyl)-6,6-dimethyl-1,6-dihydro-1...)
Affinity DataIC50:  1.44E+4nMAssay Description:The synthesized compounds were evaluated for their ability to inhibit DHFR from pc, tg, ma, and rl using a continuous spectrophotometric assay measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Institute Of Chemical Technology

LigandPNGBDBM50405043(1-(4-(Benzyloxy)phenyl)-6,6-dimethyl-1,6-dihydro-1...)
Affinity DataIC50:  32nMAssay Description:The synthesized compounds were evaluated for their ability to inhibit DHFR from pc, tg, ma, and rl using a continuous spectrophotometric assay measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Institute Of Chemical Technology

LigandPNGBDBM50405043(1-(4-(Benzyloxy)phenyl)-6,6-dimethyl-1,6-dihydro-1...)
Affinity DataIC50:  5.40E+3nMAssay Description:The synthesized compounds were evaluated for their ability to inhibit DHFR from pc, tg, ma, and rl using a continuous spectrophotometric assay measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Institute Of Chemical Technology

LigandPNGBDBM50405043(1-(4-(Benzyloxy)phenyl)-6,6-dimethyl-1,6-dihydro-1...)
Affinity DataIC50:  120nMAssay Description:The synthesized compounds were evaluated for their ability to inhibit DHFR from pc, tg, ma, and rl using a continuous spectrophotometric assay measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed