BDBM50420186 ZOSUQUIDAR::ZOSUQUIDAR TRIHYDROCHLORIDE

SMILES O[C@@H](COc1cccc2ncccc12)CN1CCN(CC1)[C@@H]1c2ccccc2[C@@H]2[C@H](c3ccccc13)C2(F)F

InChI Key InChIKey=IHOVFYSQUDPMCN-DBEBIPAYSA-N

Data  8 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50420186   

TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50420186(ZOSUQUIDAR | ZOSUQUIDAR TRIHYDROCHLORIDE)
Affinity DataKd:  73nMAssay Description:TP_TRANSPORTER: binding in membrane vesicle from CEM/VLB100 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50420186(ZOSUQUIDAR | ZOSUQUIDAR TRIHYDROCHLORIDE)
Affinity DataIC50:  24nMAssay Description:TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50420186(ZOSUQUIDAR | ZOSUQUIDAR TRIHYDROCHLORIDE)
Affinity DataIC50:  20nMAssay Description:TP_TRANSPORTER: inhibition of Nelfinavir transepithelial transport (basal to apical) (Nelfinavir: 0.02 uM) in Caco-2 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50420186(ZOSUQUIDAR | ZOSUQUIDAR TRIHYDROCHLORIDE)
Affinity DataIC50:  50nMAssay Description:TP_TRANSPORTER: inhibition of Indinavir transepithelial transport (basal to apical) (Indinavir: 0.05 uM) in Caco-2 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50420186(ZOSUQUIDAR | ZOSUQUIDAR TRIHYDROCHLORIDE)
Affinity DataIC50:  3.49E+3nMAssay Description:Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50420186(ZOSUQUIDAR | ZOSUQUIDAR TRIHYDROCHLORIDE)
Affinity DataIC50:  59nMAssay Description:Inhibition of P-glycoprotein-mediated daunorubicin efflux from human CCRF-CEM/VCR1000 cells after 240 secs by FACS flow cytometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50420186(ZOSUQUIDAR | ZOSUQUIDAR TRIHYDROCHLORIDE)
Affinity DataIC50:  180nMAssay Description:TP_TRANSPORTER: cell accumulation of calcein in L-MDR1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50420186(ZOSUQUIDAR | ZOSUQUIDAR TRIHYDROCHLORIDE)
Affinity DataIC50:  1.23E+4nMAssay Description:Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50420186(ZOSUQUIDAR | ZOSUQUIDAR TRIHYDROCHLORIDE)
Affinity DataIC50:  50nMAssay Description:TP_TRANSPORTER: inhibition of Indinavir transepithelial transport (basal to apical) (Indinavir: 0.05 uM) in Caco-2 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed