BDBM50420959 CHEMBL2088095
SMILES Cc1cc(CNc2ncc(Br)c(Nc3cc(CCc4ccccc4)n[nH]3)n2)on1
InChI Key InChIKey=BUSNTKOLFQPMBH-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50420959
Affinity DataIC50: 63.1nMAssay Description:Inhibition of human FGFR1 phosphorylation expressed in COS1 cells after 1 hr by immunoblottingMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human IGF1R phosphorylation expressed in IGF-1-stimulated knockout mouse R+ cells treated 30 mins before IGF-1 stimulation measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of human INSR phosphorylation over expressed in CHOT cells after 60 mins by immunoblottingMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of human KDR phosphorylation expressed in VEGF-stimulated HUVEC treated 90 mins before VEGF stimulation measured after 5 mins by ELISAMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 25.1nMAssay Description:Inhibition of recombinant N terminal GST-tagged human KDR (805 to 1356) expressed in baculovirus infected Sf9 cells after 90 mins by caliper mobility...More data for this Ligand-Target Pair
Affinity DataIC50: 2.51nMAssay Description:Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili...More data for this Ligand-Target Pair
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of recombinant N terminal His6-tagged human IGF1R (959 to end) expressed in baculovirus infected Sf21 cells after 80 mins by caliper mobil...More data for this Ligand-Target Pair