BDBM50425087 CHEMBL218884::US9402842, 55

SMILES COc1cccc2C(=O)c3c(-c12)n(CCCN)c(=O)c1cc(ccc31)[N+]([O-])=O

InChI Key InChIKey=ADPVBVVWMQETHS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50425087   

TargetTyrosyl-DNA phosphodiesterase 1(Homo sapiens (Human))
Purdue Research Foundation

US Patent
LigandPNGBDBM50425087(CHEMBL218884 | US9402842, 55)
Affinity DataIC50:  5.80E+3nMpH: 7.5 T: 2°CAssay Description:A 5′-[32P]-labeled single-stranded DNA oligonucleotide containing a 3′-phosphotyrosine (N14Y) was generated as described by Dexheimer et ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosyl-DNA phosphodiesterase 1(Homo sapiens (Human))
Purdue Research Foundation

US Patent
LigandPNGBDBM50425087(CHEMBL218884 | US9402842, 55)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of recombinant Tdp1 (unknown origin) using 5'-[32P]-labeled single-stranded DNA oligonucleotide containing 3'-phosphotyrosine as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 1(Homo sapiens (Human))
Purdue Research Foundation

US Patent
LigandPNGBDBM50425087(CHEMBL218884 | US9402842, 55)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human recombinant TDP1 assessed as hydrolysis of N14Y to N14P after 15 mins by PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed