BDBM50427305 CHEMBL2325720

SMILES Cc1cc(-c2nc(cc(n2)C2(CC2)S(C)(=O)=O)N2CCOCC2)c2cc[nH]c2c1

InChI Key InChIKey=NOJDPUWRXNTCAX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50427305   

TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50427305(CHEMBL2325720)
Affinity DataIC50:  490nMAssay Description:Inhibition of ATR-mediated CHK1 phosphorylation at serine 345 in human HT29 cells after 1 hr in presence of 4-nitroquinoline 1-oxideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50427305(CHEMBL2325720)
Affinity DataIC50:  8nMAssay Description:Inhibition of ATR in human HeLa cell nuclear extracts using glutathione S-transferase-p53N66 and ATP as substrate incubated for 10 mins prior to ATP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed