BDBM50427564 CHEMBL2322611

SMILES COCCCOc1cc(ccc1OC)C(=O)N(C[C@@H]1CNC[C@H]1Cc1ccccc1)C(C)C

InChI Key InChIKey=PHCCFIGNVNPMML-RPWUZVMVSA-N

Data  13 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50427564   

TargetRenin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427564(CHEMBL2322611)
Affinity DataIC50:  450nMAssay Description:Inhibition of human recombinant renin expressed in CHO cells using RE(EDANS)IHPFHLVIHTK(Dabcyl)R as substrate incubated for 1 hr prior to substrate a...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427564(CHEMBL2322611)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human recombinant BACE-1 expressed in baculovirus-infected insect sf9 cells using RE( EDANS)-EVNLDAEF-K(DABSYL)-R as substrate incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427564(CHEMBL2322611)
Affinity DataIC50:  300nMAssay Description:Inhibition of renin in human plasma using RE(EDANS)IHPFHLVIHTK(Dabcyl)R as substrate incubated for 1 hr prior to substrate addition measured after 2 ...More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427564(CHEMBL2322611)
Affinity DataIC50:  170nMAssay Description:Inhibition of recombinant human renin by fluorescence based FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427564(CHEMBL2322611)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human recombinant BACE-2 expressed in baculovirus-infected insect sf9 cells using RE( EDANS)-EVNLDAEF-K(DABSYL)-R as substrate incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastricsin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427564(CHEMBL2322611)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human recombinant pepsin C expressed in Escherichia coli using Dabcyl-E-R-Nle-F-L-S-F-P-EDANS as substrate incubated for 1 hr prior to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427564(CHEMBL2322611)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of 5-HT1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427564(CHEMBL2322611)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human recombinant cathepsin-D expressed in baculovirus-infected insect sf9 cells using Ac- E-D(EDANS)-KPILFFRLG-K(Dabcyl)-E-Amid as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427564(CHEMBL2322611)
Affinity DataIC50:  170nMAssay Description:Inhibition of human recombinant renin expressed in CHO cells using RE(EDANS)IHPFHLVIHTK(Dabcyl)R as substrate incubated for 1 hr prior to substrate a...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427564(CHEMBL2322611)
Affinity DataIC50:  1.45E+4nMAssay Description:Inhibition of human ERG by dofetilide binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427564(CHEMBL2322611)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of 5-HT2B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427564(CHEMBL2322611)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of 5-HT2A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427564(CHEMBL2322611)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human recombinant cathepsin-E expressed in Escherichia coli using Ac- E-D(EDANS)-KPILFFRLG-K(Dabcyl)-E-Amid as substrate incubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed