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BDBM50428067 CL-65336::Cyklokapron::Lysteda::TRANEXAMIC ACID::Trans Amcha

SMILES: NC[C@H]1CC[C@@H](CC1)C(O)=O

InChI Key: InChIKey=GYDJEQRTZSCIOI-LJGSYFOKSA-N

Data: 1 KI  7 IC50  4 Kd

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50428067   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Plasminogen


(Homo sapiens (human))
BDBM50428067
PNG
(CL-65336 | Cyklokapron | Lysteda | TRANEXAMIC ACID...)
Show SMILES NC[C@H]1CC[C@@H](CC1)C(O)=O
Show InChI InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-
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4.00E+7n/an/an/an/an/an/an/an/a



Kobe Gakuin University

Curated by ChEMBL


Assay Description
Inhibition of human plasmin assessed as inhibition of amidolysis in presence of fibrinogen


Bioorg Med Chem 24: 545-53 (2016)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Plasminogen


(Homo sapiens (human))
BDBM50428067
PNG
(CL-65336 | Cyklokapron | Lysteda | TRANEXAMIC ACID...)
Show SMILES NC[C@H]1CC[C@@H](CC1)C(O)=O
Show InChI InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-
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n/an/an/a 2.20E+3n/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Binding affinity to human plasma N-terminal truncated Lys-plasminogen K1 domain by surface plasmon resonance analysis


ACS Med Chem Lett 5: 538-43 (2014)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Plasminogen


(Homo sapiens (human))
BDBM50428067
PNG
(CL-65336 | Cyklokapron | Lysteda | TRANEXAMIC ACID...)
Show SMILES NC[C@H]1CC[C@@H](CC1)C(O)=O
Show InChI InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-
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n/an/an/a 3.60E+4n/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Binding affinity to human plasma N-terminal truncated Lys-plasminogen by surface plasmon resonance analysis


ACS Med Chem Lett 5: 538-43 (2014)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Plasminogen


(Homo sapiens (human))
BDBM50428067
PNG
(CL-65336 | Cyklokapron | Lysteda | TRANEXAMIC ACID...)
Show SMILES NC[C@H]1CC[C@@H](CC1)C(O)=O
Show InChI InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-
PDB
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n/an/an/a 7.50E+5n/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Binding affinity to human plasma full length Glu-plasminogen by surface plasmon resonance analysis


ACS Med Chem Lett 5: 538-43 (2014)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Plasminogen


(Homo sapiens (human))
BDBM50428067
PNG
(CL-65336 | Cyklokapron | Lysteda | TRANEXAMIC ACID...)
Show SMILES NC[C@H]1CC[C@@H](CC1)C(O)=O
Show InChI InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-
PDB
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n/an/a 1.20E+4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Binding affinity to human full length Glu-plasminogen in buffer assessed as inhibition of interaction with fibrin preincubated for 15 mins followed b...


ACS Med Chem Lett 5: 538-43 (2014)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Plasminogen


(Homo sapiens (human))
BDBM50428067
PNG
(CL-65336 | Cyklokapron | Lysteda | TRANEXAMIC ACID...)
Show SMILES NC[C@H]1CC[C@@H](CC1)C(O)=O
Show InChI InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-
PDB
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n/an/a 1.15E+4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human Glu-plasminogen/fibrinogen interaction in HEPES buffer assessed as inhibition of lysis of thrombin-induced clot preincubated for ...


J Med Chem 56: 3273-80 (2013)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Plasminogen


(Homo sapiens (human))
BDBM50428067
PNG
(CL-65336 | Cyklokapron | Lysteda | TRANEXAMIC ACID...)
Show SMILES NC[C@H]1CC[C@@H](CC1)C(O)=O
Show InChI InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-
PDB
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n/an/a 2.00E+6n/an/an/an/an/an/a



Kyoto Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) after 18 hrs by arianor mahogany dye-based fibrin plate assay


Bioorg Med Chem Lett 25: 2702-6 (2015)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Plasminogen


(Homo sapiens (human))
BDBM50428067
PNG
(CL-65336 | Cyklokapron | Lysteda | TRANEXAMIC ACID...)
Show SMILES NC[C@H]1CC[C@@H](CC1)C(O)=O
Show InChI InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-
PDB
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PubMed
n/an/a 1.00E+7n/an/an/an/an/an/a



Kobe Gakuin University

Curated by ChEMBL


Assay Description
Inhibition of human plasmin assessed as inhibition of fibrinogenolysis in presence of fibrinogen


Bioorg Med Chem 24: 545-53 (2016)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Plasminogen


(Homo sapiens (human))
BDBM50428067
PNG
(CL-65336 | Cyklokapron | Lysteda | TRANEXAMIC ACID...)
Show SMILES NC[C@H]1CC[C@@H](CC1)C(O)=O
Show InChI InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-
PDB
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PubMed
n/an/a 5.00E+4n/an/an/an/an/an/a



Kobe Gakuin University

Curated by ChEMBL


Assay Description
Inhibition of human plasmin assessed as inhibition of fibrinolysis in presence of fibrinogen


Bioorg Med Chem 24: 545-53 (2016)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Plasminogen


(Homo sapiens (human))
BDBM50428067
PNG
(CL-65336 | Cyklokapron | Lysteda | TRANEXAMIC ACID...)
Show SMILES NC[C@H]1CC[C@@H](CC1)C(O)=O
Show InChI InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-
PDB
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Article
PubMed
n/an/a 3.10E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of plasminogen/fibrinogen interaction in pooled citrated human platelet-poor plasma assessed as inhibition of lysis of CaCl2/t-PA-induced ...


J Med Chem 56: 3273-80 (2013)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Plasminogen


(Homo sapiens (human))
BDBM50428067
PNG
(CL-65336 | Cyklokapron | Lysteda | TRANEXAMIC ACID...)
Show SMILES NC[C@H]1CC[C@@H](CC1)C(O)=O
Show InChI InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-
PDB
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PDB
UniChem
DrugBank
PDB
Article
PubMed
n/an/an/a 1.10E+3n/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Binding affinity to human plasma full length Glu-plasminogen K1 domain by surface plasmon resonance analysis


ACS Med Chem Lett 5: 538-43 (2014)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Plasminogen


(Homo sapiens (human))
BDBM50428067
PNG
(CL-65336 | Cyklokapron | Lysteda | TRANEXAMIC ACID...)
Show SMILES NC[C@H]1CC[C@@H](CC1)C(O)=O
Show InChI InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-
PDB
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UniChem
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Article
PubMed
n/an/a 3.10E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPA


ACS Med Chem Lett 5: 538-43 (2014)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)