BDBM50428340 CHEMBL2331712
SMILES NC1=N[C@]2(C[C@H]2CCS1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
InChI Key InChIKey=COCAUCFPFHUGAA-MGNBDDOMSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50428340
Affinity DataIC50: 26nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing APP695 assessed as inhibition of amyloid beta (1 to 40) production after 18 to 20 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of BACE2-mediated TMEM27 cleavage in rat INS-1E cells expressing doxycycline-dependent human full-length TMEM27 by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human wild type APP695 assessed as decrease in amyloid beta 40 level after 18 to 20 hrs by...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of BACE2 in rat INS-1E cells assessed as TMEM27 cleavage preincubated for 2 hrs followed by doxycycline addition measured after 46 hrs by ...More data for this Ligand-Target Pair