BDBM50428715 CHEMBL2333129::US9884828, 2-19

SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc2c(NC3CCC3)c(nnc2c1)C(N)=O

InChI Key InChIKey=DVEKPOFBEAWBKW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50428715   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50428715(CHEMBL2333129 | US9884828, 2-19)
Affinity DataIC50:  10nMAssay Description:Inhibition of wild type GST-tagged LRRK2 (970 to 2527 amino acid residues) (unknown origin) assessed as inhibition of biotinylated-LRRKtide phosphory...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50428715(CHEMBL2333129 | US9884828, 2-19)
Affinity DataIC50:  10nMpH: 7.5 T: 2°CAssay Description:Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50428715(CHEMBL2333129 | US9884828, 2-19)
Affinity DataIC50:  22nMAssay Description:Inhibition of PDGFRalpha (unknown origin) by TR-FRET assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed