BDBM50431015 CHEMBL2338329::US10889546, FG-4592::US9115085, Compound A Form A::US9340511, 3

SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3ccccc3)cc12

InChI Key InChIKey=YOZBGTLTNGAVFU-UHFFFAOYSA-N

Data  1 KI  17 IC50  3 EC50

PDB links: 5 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50431015   

TargetProlyl 4-hydroxylase(Paramecium bursaria Chlorella virus 1)
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50431015(CHEMBL2338329 | US10889546, FG-4592 | US9115085, C...)
Affinity DataKi:  1.07E+3nMAssay Description:Inhibition of N-terminal His6-tagged recombinant Paramecium bursaria chlorella virus 1 CPH expressed in Escherichia coli Rosetta 2 (DE3) cells pre-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50431015(CHEMBL2338329 | US10889546, FG-4592 | US9115085, C...)
Affinity DataIC50:  47nMAssay Description:Inhibition of PHD2 (unknown origin) incubated for 15 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50431015(CHEMBL2338329 | US10889546, FG-4592 | US9115085, C...)
Affinity DataIC50:  591nMAssay Description:Displacement of FITC-HIF-1alpha (556 to 574 residues) from PHD2 (181 to 426 residues) (unknown origin) after 60 mins by fluorescence polarization ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50431015(CHEMBL2338329 | US10889546, FG-4592 | US9115085, C...)
Affinity DataIC50:  9.80E+3nMAssay Description:Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50431015(CHEMBL2338329 | US10889546, FG-4592 | US9115085, C...)
Affinity DataIC50:  5.74E+3nMAssay Description:Inhibition of HIF-PHD2 (181 to 426 residues) (unknown origin) using HIF1-alpha (556 to 574 residues) as substrate in presence of 2-OG preincubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50431015(CHEMBL2338329 | US10889546, FG-4592 | US9115085, C...)
Affinity DataIC50:  591nMAssay Description:Inhibition of HIF-PHD2 (181 to 426 residues) (unknown origin) using FITC-HIF1-alpha (556 to 574 residues) as substrate after 60 mins by fluorescence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50431015(CHEMBL2338329 | US10889546, FG-4592 | US9115085, C...)
Affinity DataIC50:  27nMAssay Description:Inhibition of recombinant human PHD2 using 2OG as substrate and Fe2 as co-factor assessed as hydroxylation incubated for 15 mins in presence of L-asc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl 4-hydroxylase(Paramecium bursaria Chlorella virus 1)
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50431015(CHEMBL2338329 | US10889546, FG-4592 | US9115085, C...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of N-terminal His6-tagged recombinant Paramecium bursaria chlorella virus 1 CPH expressed in Escherichia coli Rosetta 2 (DE3) cells pre-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha inhibitor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50431015(CHEMBL2338329 | US10889546, FG-4592 | US9115085, C...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human FIH using 2OG as substrate and Fe2 as co-factor assessed as hydroxylation incubated for 15 mins in presence of L-asco...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl 3-hydroxylase OGFOD1(Homo sapiens)
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50431015(CHEMBL2338329 | US10889546, FG-4592 | US9115085, C...)
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of recombinant human OGFOD1 using 2OG as substrate and Fe2 as co-factor assessed as hydroxylation incubated for 15 mins in presence of L-a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50431015(CHEMBL2338329 | US10889546, FG-4592 | US9115085, C...)
Affinity DataIC50:  575nMAssay Description:Inhibition of PHD2 (181 to 426 residues) (unknown origin) using FITC-HIF1alpha (556 to 574 residues) as substrate after 60 mins by fluorescence polar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50431015(CHEMBL2338329 | US10889546, FG-4592 | US9115085, C...)
Affinity DataIC50:  599nMAssay Description:The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALD...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEgl nine homolog 1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50431015(CHEMBL2338329 | US10889546, FG-4592 | US9115085, C...)
Affinity DataIC50:  32nMAssay Description:Inhibition of HIF-PHD2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50431015(CHEMBL2338329 | US10889546, FG-4592 | US9115085, C...)
Affinity DataIC50:  591nMAssay Description:Inhibition of FITC-HIF1alpha (556 to 574 residues) binding to PHD2 (181 to 426 residues) (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50431015(CHEMBL2338329 | US10889546, FG-4592 | US9115085, C...)
Affinity DataIC50:  520nMAssay Description:Inhibition of PHD2 (unknown origin) measured by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50431015(CHEMBL2338329 | US10889546, FG-4592 | US9115085, C...)
Affinity DataIC50:  121nMAssay Description:Inhibition of PHD2 (181 to 426 residue) (unknown origin) measured by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50431015(CHEMBL2338329 | US10889546, FG-4592 | US9115085, C...)
Affinity DataEC50:  33nMAssay Description:Agonist activity at wild type human TR alpha LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of N-terminal biotinylated coactivato...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50431015(CHEMBL2338329 | US10889546, FG-4592 | US9115085, C...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human TR beta LBD (202 to 461 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as induction of N-terminal biotin...More data for this Ligand-Target Pair
TargetEgl nine homolog 1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50431015(CHEMBL2338329 | US10889546, FG-4592 | US9115085, C...)
Affinity DataEC50:  6.11E+3nMAssay Description:Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO production measured after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50431015(CHEMBL2338329 | US10889546, FG-4592 | US9115085, C...)
Affinity DataIC50:  2.10E+3nMpH: 7.4Assay Description:Ketoglutaric acid alpha -[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide were obtained from commercial sources, e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEgl nine homolog 1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50431015(CHEMBL2338329 | US10889546, FG-4592 | US9115085, C...)
Affinity DataIC50:  2.10E+3nMpH: 7.4Assay Description:Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide were obtained from commercial sources, ...More data for this Ligand-Target Pair
In DepthDetails US Patent