BDBM50431519 CHEMBL2348862

SMILES CC(C)(O)c1ccc(cn1)-c1cnc2NC(=O)CN(CC3CCOCC3)c2n1

InChI Key InChIKey=UWUPKVZQISLSSA-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50431519   

LigandPNGBDBM50431519(CHEMBL2348862)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of PI3K-alpha (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFKBP12A/mTOR(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50431519(CHEMBL2348862)
Affinity DataIC50:  390nMAssay Description:Inhibition of mTORC1 in human PC3 cells assessed as inhibition of S6 phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50431519(CHEMBL2348862)
Affinity DataIC50:  106nMAssay Description:Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50431519(CHEMBL2348862)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of FMS (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Homo sapiens)
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50431519(CHEMBL2348862)
Affinity DataIC50:  386nMAssay Description:Inhibition of mTORC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50431519(CHEMBL2348862)
Affinity DataIC50:  106nMAssay Description:Inhibition of recombinant mTOR (unknown origin) using GST-p70S6 as substrate after 60 mins by TR-FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50431519(CHEMBL2348862)
Affinity DataIC50:  315nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50431519(CHEMBL2348862)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50431519(CHEMBL2348862)
Affinity DataIC50:  106nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50431519(CHEMBL2348862)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed