BDBM50432338 CHEMBL2348176::US9616064, Compound 15a

SMILES Nc1nccc(n1)-n1ccc2ccccc12

InChI Key InChIKey=QNZSVEIPQWPBJO-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50432338   

TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50432338(CHEMBL2348176 | US9616064, Compound 15a)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CDC7 in human HCT116 cells assessed as MCM2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50432338(CHEMBL2348176 | US9616064, Compound 15a)
Affinity DataIC50:  2.85E+4nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute

US Patent
LigandPNGBDBM50432338(CHEMBL2348176 | US9616064, Compound 15a)
Affinity DataIC50:  4.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute

US Patent
LigandPNGBDBM50432338(CHEMBL2348176 | US9616064, Compound 15a)
Affinity DataIC50:  4.80E+3nMAssay Description:The inventors undertook a screen of the NCI Diversity set using a Z-lyte FRET assay (Kang et al. (2009); Wu et al. (2010)) to measure kinase inhibiti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50432338(CHEMBL2348176 | US9616064, Compound 15a)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of CDC7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed