BDBM50433562 CHEMBL1818538::Nutlin-1

SMILES COc1ccc(C2=NC(C(N2C(=O)N2CCN(CC2)C(C)=O)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1

InChI Key InChIKey=IYDMGGPKSVWQRT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50433562   

TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Jss Academy Of Higher Education And Research

Curated by ChEMBL
LigandPNGBDBM50433562(CHEMBL1818538 | Nutlin-1)
Affinity DataIC50:  260nMAssay Description:Inhibition of recombinant p53 protein binding to recombinant human MDM2 by surface plasmon resonance methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Jss Academy Of Higher Education And Research

Curated by ChEMBL
LigandPNGBDBM50433562(CHEMBL1818538 | Nutlin-1)
Affinity DataIC50:  100nMAssay Description:Antagonist activity at human GST-tagged MDM2 assessed as inhibition of binding to full length p53More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed