BDBM50435473 CHEMBL1236620

SMILES CCOC(=O)c1c(C(C=N)C#N)c2ccc(Cl)c(Cl)c2n1C

InChI Key InChIKey=DXZRBHUCOHBAHP-UHFFFAOYSA-N

Data  7 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50435473   

TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant CLK1 (148 to 484 amino acids) expressed in Escherichia coli BL21(DE3) using AFRREWSPGKEAKK as substrate preincubated ...More data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataKd: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails

TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataIC50:  530nMAssay Description:Inhibition of human recombinant CLK3 (275 to 632 amino acids) expressed in Escherichia coli BL21(DE3) preincubated for 10 mins prior to substrate add...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataIC50:  55nMAssay Description:Inhibition of DYRK1A (unknown origin) using YRASPSRPESPRPPA-amide as substrate preincubated for 10 mins followed by substrate addition and measured a...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant human CLK1 (130 to end residues) using ERMRPRKRQGSVRRRV as substrate incubated for 40 mins in presence of [gamma33P-ATP] by...More data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataIC50:  20nMAssay Description:Inhibition of CLK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails PubMed
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataIC50:  55nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails PubMed
Copy BDB DOI

TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))TBA

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoMMDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails

TargetCasein kinase I isoform epsilon(Homo sapiens (Human))TBA

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails

TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataIC50:  14nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails

TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataIC50:  50nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails

TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataIC50:  966nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails

TargetDual specificity protein kinase CLK4(Homo sapiens (Human))TBA

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataIC50:  15nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataIC50:  28nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))TBA

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataIC50:  187nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails

TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))TBA

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails

TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Homo sapiens (Human))TBA

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails

TargetDual specificity tyrosine-phosphorylation-regulated kinase 4(Homo sapiens (Human))TBA

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails

TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails

TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataIC50:  13nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataIC50:  22nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))TBA

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataIC50:  81nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataKd:  109nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails

TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataKd:  2.80nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL

LigandBDBM50435473(CHEMBL1236620)Copy SMILESCopy InChI

Affinity DataIC50:  55nMAssay Description:Inhibition of DYRK1A (unknown origin) using YRASPSRPESPRPPA-NH2 as substrate preincubated for 10 mins prior to substrate addition by LDH assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI