BDBM50435473 CHEMBL1236620
SMILES CCOC(=O)c1c(C(C=N)C#N)c2ccc(Cl)c(Cl)c2n1C
InChI Key InChIKey=DXZRBHUCOHBAHP-UHFFFAOYSA-N
Data 7 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50435473
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by ChEMBL
University Of Kansas Specialized Chemistry Center
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant CLK1 (148 to 484 amino acids) expressed in Escherichia coli BL21(DE3) using AFRREWSPGKEAKK as substrate preincubated ...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by ChEMBL
University Of Kansas Specialized Chemistry Center
Curated by ChEMBL
Affinity DataIC50: 55nMAssay Description:Inhibition of DYRK1A (unknown origin) using YRASPSRPESPRPPA-NH2 as substrate preincubated for 10 mins prior to substrate addition by LDH assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by ChEMBL
University Of Kansas Specialized Chemistry Center
Curated by ChEMBL
Affinity DataIC50: 530nMAssay Description:Inhibition of human recombinant CLK3 (275 to 632 amino acids) expressed in Escherichia coli BL21(DE3) preincubated for 10 mins prior to substrate add...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by ChEMBL
University Of Kansas Specialized Chemistry Center
Curated by ChEMBL
Affinity DataIC50: 55nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by ChEMBL
University Of Kansas Specialized Chemistry Center
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human CLK1 (130 to end residues) using ERMRPRKRQGSVRRRV as substrate incubated for 40 mins in presence of [gamma33P-ATP] by...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of CLK2 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by ChEMBL
University Of Kansas Specialized Chemistry Center
Curated by ChEMBL
Affinity DataIC50: 55nMAssay Description:Inhibition of DYRK1A (unknown origin) using YRASPSRPESPRPPA-amide as substrate preincubated for 10 mins followed by substrate addition and measured a...More data for this Ligand-Target Pair