BindingDB PrimarySearch

BDBM50436850 CERITINIB::CHEMBL2403108::LDK378

SMILES: CC(C)Oc1cc(C2CCNCC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1

InChI Key: InChIKey=VERWOWGGCGHDQE-UHFFFAOYSA-N

Data: 44 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 44 hits for monomerid = 50436850
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center Curated by ChEMBL					Assay Description Inhibition of ALK (unknown origin) transfected in mouse BA/F3 cells				J Med Chem 56: 5673-4 (2014)
					More data for this Ligand-Target Pair				3D Structure (crystal)
Neurotrophic tyrosine kinase receptor (Homo Sapiens)	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.73E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of TEL-fused TRKA (unknown origin) by cell-based assay				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
IRE1α (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington					Assay Description Inhibitors (initial concentration 10 or 60 μM, three-fold serial dilutions) were incubated with IRE1α* in cleavage buffer (20 mM HEPES at p...				ACS Chem Biol 11: 2195-205 (2016)
University of Washington					More data for this Ligand-Target Pair
NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Institute of Materia Medica (SIMM) Curated by ChEMBL					Assay Description Inhibition of purified ALK (unknown origin) after 60 mins by ELISA kinase assay				Eur J Med Chem 86: 438-48 (2014)
					More data for this Ligand-Target Pair				3D Structure (crystal)
NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Chemical Technology Curated by ChEMBL					Assay Description Inhibition of wild type ALK (unknown origin) by homogeneous time resolved fluorescence assay				Citation and Details
					More data for this Ligand-Target Pair				3D Structure (crystal)
NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Chemical Technology Curated by ChEMBL					Assay Description Inhibition of ALK L1196M mutant (unknown origin) by homogeneous time resolved fluorescence assay				Citation and Details
					More data for this Ligand-Target Pair				3D Structure (crystal)
Insulin receptor (Homo sapiens (human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Chemical Technology Curated by ChEMBL					Assay Description Inhibition of insulin receptor (unknown origin) by homogeneous time resolved fluorescence assay				Citation and Details
					More data for this Ligand-Target Pair
NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Chungbuk National University Curated by ChEMBL					Assay Description Inhibition of wild type ALK (unknown origin) after 30 mins by HTRF assay				Citation and Details
Chungbuk National University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Chungbuk National University Curated by ChEMBL					Assay Description Inhibition of ALK L1196M mutant (unknown origin) after 30 mins by HTRF assay				Citation and Details
Chungbuk National University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of c-Met (unknown origin) using peptide as substrate after 60 mins by HTRF assay				Citation and Details
Shenyang Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
EML4-ALK (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of ALK (unknown origin) using peptide as substrate after 60 mins by HTRF assay				Citation and Details
Shenyang Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Proto-oncogene tyrosine-protein kinase ROS (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of ROS1 (unknown origin) using peptide as substrate after 60 mins by HTRF assay				Citation and Details
Shenyang Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of EGFR (unknown origin) using peptide as substrate after 60 mins by HTRF assay				Citation and Details
Shenyang Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.27E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) after 60 mins				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of ABL (unknown origin) after 60 mins				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of PDGFRalpha (unknown origin) after 60 mins				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	610	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin) after 60 mins				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of RET (unknown origin) after 60 mins				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3 (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of FLT3 (unknown origin) after 60 mins				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
Testis-specific serine/threonine-protein kinase 1 (Homo sapiens)	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of STK22D (unknown origin) after 60 mins				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of IGF1 receptor (unknown origin) after 60 mins				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of insulin receptor (unknown origin) after 60 mins				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of ALK (unknown origin) after 60 mins				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair				3D Structure (crystal)
NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of NPM-fused ALK (unknown origin) expressed in mouse BAF3 cells after 2 to 3 days by luciferase reporter gene assay				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase ZAP-70 (Homo sapiens (human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	9.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of ZAP70 (unknown origin) after 60 mins				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
JAK3/JAK1 (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	7.92E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of JAK3 (unknown origin) after 60 mins				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.73E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of JAK1 (unknown origin) after 60 mins				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.36E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of BTK (unknown origin) after 60 mins				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.17E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of cMET (unknown origin) after 60 mins				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of SYK (unknown origin) after 60 mins				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
MAP kinase signal-integrating kinase 2 (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of MKNK2 (unknown origin) after 60 mins				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of EML4-fused ALK (unknown origin) by cell-based assay				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair				3D Structure (crystal)
Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of TEL-fused RET (unknown origin) by cell-based assay				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.16E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of TEL-fused JAK2 (unknown origin) by cell-based assay				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
Neurotrophic tyrosine kinase receptor type 2 (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.83E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of TEL-fused TRKB (unknown origin) by cell-based assay				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of TEL-fused MET (unknown origin) by cell-based assay				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of TEL-fused IGF1 receptor (unknown origin) by cell-based assay				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of TEL-fused insulin receptor (unknown origin) expressed in mouse BAF3 cells after 2 to 3 days by luciferase reporter gene assay				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	142	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of TEL-fused ROS (unknown origin) by cell-based assay				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of TEL-fused ALK (unknown origin) by cell-based assay				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair				3D Structure (crystal)
p21-Activated kinase 2 (PAK2) (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of PAK2 (unknown origin) after 60 mins				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
Transcription factor ETV6 (Homo sapiens)	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of wild-type TEL (unknown origin) by cell-based assay				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3 (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of TEL-fused FLT3 (unknown origin) by cell-based assay				J Med Chem 56: 5675-90 (2014)
					More data for this Ligand-Target Pair
NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) (Homo sapiens (Human))	BDBM50436850 (CERITINIB \| CHEMBL2403108 \| LDK378) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center Curated by ChEMBL					Assay Description Inhibition of ALK (unknown origin)				J Med Chem 56: 5673-4 (2014)
					More data for this Ligand-Target Pair				3D Structure (crystal)