BDBM85747 CAS_442-52-4::CLEMIZOLE HYDROCHLORIDE::NSC_2782::clemizole
SMILES Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc23)cc1
InChI Key InChIKey=CJXAEXPPLWQRFR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 85747
TargetHistamine H4 receptor(Human)
The Centre For Addiction and Mental Health
Curated by PDSP Ki Database
The Centre For Addiction and Mental Health
Curated by PDSP Ki Database
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HO-1 in Sprague-Dawley rat spleen microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas ch...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...More data for this Ligand-Target Pair
TargetShort transient receptor potential channel 6(Human)
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 1.13E+4nMAssay Description:Inhibition of YFP-tagged human TRPC6 expressed in thapsigargin treated HEK293 cells assessed as reduction in amix-induced calcium level by fluo-4 dye...More data for this Ligand-Target Pair
TargetShort transient receptor potential channel 4(Mouse)
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of YFP-tagged mouse TRPC4 beta expressed in thapsigargin treated HEK293 cells co-expressing M3 receptor assessed as reduction in carbachol...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CFP-tagged rat TRPV1 expressed in HEK293 cells assessed as reduction in calcium level by fluo-4 dye based fluorescence assayMore data for this Ligand-Target Pair
TargetShort transient receptor potential channel 7(Mouse)
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 2.65E+4nMAssay Description:Inhibition of YFP-tagged mouse TRPC7 expressed in thapsigargin treated HEK293 cells assessed as reduction in amix-induced calcium level by fluo-4 dye...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of YFP-tagged rat TRPV3 expressed in HEK293 cells assessed as reduction in calcium level by fluo-4 dye based fluorescence assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Mouse)
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of YFP-tagged mouse TRPV4 expressed in HEK293 cells assessed as reduction in calcium level by fluo-4 dye based fluorescence assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 2(Rat)
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of YFP-tagged rat TRPV2 expressed in HEK293 cells assessed as reduction in calcium level by fluo-4 dye based fluorescence assayMore data for this Ligand-Target Pair
TargetShort transient receptor potential channel 5(Mouse)
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of mouse TRPC5 expressed in thapsigargin treated HEK293/TREx cells assessed as reduction in intracellular calcium level in presence of GPC...More data for this Ligand-Target Pair
3D Structure (crystal)TargetPotassium voltage-gated channel subfamily H member 2(Human)
The Board of Trustees of The Leland Stanford Junion University
US Patent
The Board of Trustees of The Leland Stanford Junion University
US Patent
Affinity DataIC50: <1.00E+3nMAssay Description:Drugs belonging to different classes have been shown to be associated with QT prolongation and in some cases serious ventricular arrhythmias. The mos...More data for this Ligand-Target Pair
TargetShort transient receptor potential channel 3(Human)
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of YFP-tagged human TRPC3 expressed in thapsigargin treated HEK293 cells assessed as reduction in amix-induced calcium level by fluo-4 dye...More data for this Ligand-Target Pair