BDBM50442600 CHEMBL2441437::US9056859, 1

SMILES O=C(Cc1ccc(cc1)-n1cnnn1)N1CCN(CCc2ccc3C(=O)OCc3c2)CC1

InChI Key InChIKey=LKLRNYYBQWYHND-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50442600   

TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50442600(CHEMBL2441437 | US9056859, 1)
Affinity DataIC50:  65nMpH: 7.4Assay Description:Block of Kir1.1 (ROMKI) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442600(CHEMBL2441437 | US9056859, 1)
Affinity DataIC50:  64nMAssay Description:Inhibition of ROMK (unknown origin) expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442600(CHEMBL2441437 | US9056859, 1)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442600(CHEMBL2441437 | US9056859, 1)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of human ERG by electrophysiology analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442600(CHEMBL2441437 | US9056859, 1)
Affinity DataIC50:  64nMAssay Description:Inhibition of human ROMK expressed in CHO cells by whole-cell voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442600(CHEMBL2441437 | US9056859, 1)
Affinity DataIC50:  110nMAssay Description:Inhibition of human ROMK channel-mediated 86Rb+ flux expressed in CHO cells after 35 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442600(CHEMBL2441437 | US9056859, 1)
Affinity DataIC50:  110nMAssay Description:Inhibition of human ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInward rectifier potassium channel 13(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442600(CHEMBL2441437 | US9056859, 1)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Kir7.1 channel (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 10(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442600(CHEMBL2441437 | US9056859, 1)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Kir4.1 channel (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInward rectifier potassium channel 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442600(CHEMBL2441437 | US9056859, 1)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Kir2.3 channel (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInward rectifier potassium channel 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442600(CHEMBL2441437 | US9056859, 1)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Kir2.1 channel (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442600(CHEMBL2441437 | US9056859, 1)
Affinity DataIC50:  64nMAssay Description:Inhibition of human ROMK channel by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442600(CHEMBL2441437 | US9056859, 1)
Affinity DataIC50:  1.40E+3nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50442600(CHEMBL2441437 | US9056859, 1)
Affinity DataIC50:  113nMAssay Description:Inhibition of rat ROMK channel-mediated 86Rb+ fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed