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BDBM50444655 CHEMBL3098518

SMILES: Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(NC#N)=Nc2ccncc2)cc1

InChI Key: InChIKey=LBCFMUZZSLJNDC-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50444655   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50444655
PNG
(CHEMBL3098518)
Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(NC#N)=Nc2ccncc2)cc1
Show InChI InChI=1S/C20H15F2N5O2S/c21-15-9-16(22)11-19(10-15)30(28,29)18-3-1-14(2-4-18)12-25-20(26-13-23)27-17-5-7-24-8-6-17/h1-11H,12H2,(H2,24,25,26,27)
PDB
MMDB

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Similars

Article
PubMed
n/an/a 0.600n/an/an/an/an/an/a



Forma Therapeutics, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Nampt (unknown origin) using nicotinamide as substrate preincubated for 15 mins measured after 30 mins by mass spectrometry analysis


Bioorg Med Chem Lett 24: 337-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.11.006
BindingDB Entry DOI: 10.7270/Q2CJ8FZH
More data for this
Ligand-Target Pair