BDBM50446293 CHEMBL3109225

SMILES CCCN(CCc1ccc(cc1)C(F)(F)F)c1ccc(NC(=O)Cc2ccc(cc2)S(=O)(=O)CC)cc1

InChI Key InChIKey=FATVRKBOUMMQKT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50446293   

TargetNuclear receptor ROR-gamma(Mus musculus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50446293(CHEMBL3109225)
Affinity DataIC50:  733nMAssay Description:Inverse agonist activity at RORgammat in mouse Th17 cells assessed as effect on cell differentiation measured as IL-17 level after 3 days by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50446293(CHEMBL3109225)
Affinity DataIC50:  79nMAssay Description:Inverse agonist activity at biotinylated human RORgammat LBD expressed in Escherichia coli BL21 assessed as inhibition of SRC1 recruitment after 1 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed