BDBM50447777 CHEMBL3113537::US9242970, 220

SMILES COc1cccc(F)c1C1CCCC(=O)N1Cc1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=QFJWRHMGPXIECF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50447777   

TargetOrexin receptor type 2(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM50447777(CHEMBL3113537 | US9242970, 220)
Affinity DataIC50:  156nMT: 2°CAssay Description:In Vitro Assay: Intracellular Calcium Measurements:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 re...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM50447777(CHEMBL3113537 | US9242970, 220)
Affinity DataIC50:  161nMAssay Description:Antagonist activity at human orexin 2 receptor expressed in CHO cells assessed as inhibition of orexin-A-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50447777(CHEMBL3113537 | US9242970, 220)
Affinity DataIC50:  1.25E+3nMAssay Description:Antagonist activity at human orexin 1 receptor expressed in CHO cells assessed as inhibition of orexin-A-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50447777(CHEMBL3113537 | US9242970, 220)
Affinity DataIC50:  1.34E+3nMT: 2°CAssay Description:In Vitro Assay: Intracellular Calcium Measurements:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 re...More data for this Ligand-Target Pair
In DepthDetails US Patent