BDBM50448706 CHEMBL3127854

SMILES COc1nc([C@H]2CCCO2)c(s1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2

InChI Key InChIKey=XCUHEQGKBQYLBY-MCMXVRIYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50448706   

Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50448706(CHEMBL3127854)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of N-terminal 6-His-tagged full-length human 11beta-HSD1 assessed as conversion of cortisone to cortisol after 25 mins by competitive HTRF...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50448706(CHEMBL3127854)
Affinity DataIC50:  34nMAssay Description:Inhibition of N-terminal 6-His-tagged full-length mouse 11beta-HSD1 assessed as conversion of cortisone to cortisol after 25 mins by competitive HTRF...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50448706(CHEMBL3127854)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of recombinant human 11beta-HSD1 using cortisone/[3H]-cortisone as substrate after 5 hrs by reverse-phase HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed