BDBM50448787 CHEMBL3128178
SMILES O[C@@H]([C@H]1CC[C@@H](Cc2ccc(NC(=O)[C@@H]3CCc4scnc34)cc2)N1)c1cccnc1
InChI Key InChIKey=OYURTPRHVJSKRC-DZCCDHAISA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50448787
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 420nMAssay Description:Inhibition of human SERT expressed in HEK293 cells preincubated for 30 mins followed by fluorescent substrate addition measured after 30 mins by plat...More data for this Ligand-Target Pair
Affinity DataEC50: 1.40nMAssay Description:Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Displacement of [125]I-cyanopindolol from recombinant human beta1 adrenergic receptor after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Displacement of [125]I-cyanopindolol from human recombinant beta2 adrenergic receptor after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as diclofenac alpha'-hydroxylationMore data for this Ligand-Target Pair
Affinity DataIC50: 7.90E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as dextraomethorphan O-demethylationMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as diclofenac alpha'-hydroxylationMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 6.10E+3nMAssay Description:Binding affinity to human ERG channelMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Displacement of [3H]-diltiazem from human Cav1.2 channelMore data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human Nav1.2 channel expressed in Xenopus oocytes by two-intracellular microelectrode voltage clamp methodMore data for this Ligand-Target Pair
Affinity DataIC50: 7.88E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as dextromethorphan O-demethylationMore data for this Ligand-Target Pair
Affinity DataEC50: 5nMAssay Description:Agonist activity at dog beta-3 adrenergic receptor expressed in CHO cells assessed as increase in intracellular cAMP accumulation after 30 mins by ti...More data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Agonist activity at rhesus monkey beta-3 adrenergic receptor expressed in CHO cells assessed as increase in intracellular cAMP accumulation after 30 ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as testosterone 6beta-hydroxylationMore data for this Ligand-Target Pair