BDBM50449787 CHEMBL2062154::PD-134308
SMILES [H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)C(OC(=O)N[C@](C)(Cc1c[nH]c4ccccc14)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1)[C@@]([H])(C2)C3
InChI Key InChIKey=FVQSSYMRZKLFDR-QRCSZXLUSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 23 hits for monomerid = 50449787
Affinity DataKi: 0.148nMAssay Description:Inhibition by displacing [3H]CCK-8S against Cholecystokinin type A receptor of rat pancreatic membranesMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Glaxo Wellcome Medicines Research Centre
Curated by ChEMBL
Glaxo Wellcome Medicines Research Centre
Curated by ChEMBL
Affinity DataKi: 0.355nMAssay Description:Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptorMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Glaxo Wellcome Medicines Research Centre
Curated by ChEMBL
Glaxo Wellcome Medicines Research Centre
Curated by ChEMBL
Affinity DataKi: 0.400nMAssay Description:Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.More data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Glaxo Wellcome Medicines Research Centre
Curated by ChEMBL
Glaxo Wellcome Medicines Research Centre
Curated by ChEMBL
Affinity DataKi: 0.980nMAssay Description:The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.More data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Glaxo Wellcome Medicines Research Centre
Curated by ChEMBL
Glaxo Wellcome Medicines Research Centre
Curated by ChEMBL
Affinity DataKi: 1.90nMAssay Description:Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pigMore data for this Ligand-Target Pair
Affinity DataKi: 7.30nMAssay Description:Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.More data for this Ligand-Target Pair
Affinity DataKi: 269nMAssay Description:Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranesMore data for this Ligand-Target Pair
Affinity DataKi: 631nMAssay Description:Displacement of [125I]BH-CCK-8S from CC1 receptor expressed in guinea pig pancreatic cellsMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Glaxo Wellcome Medicines Research Centre
Curated by ChEMBL
Glaxo Wellcome Medicines Research Centre
Curated by ChEMBL
Affinity DataIC50: 0.138nMAssay Description:In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type A receptor in the rat pancreasMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of [125I]CCK-8 binding to Cholecystokinin type A receptor in the rat pancreasMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexMore data for this Ligand-Target Pair
TargetCholecystokinin receptor type A(Homo sapiens (Human))
Glaxo Research Institute
Curated by ChEMBL
Glaxo Research Institute
Curated by ChEMBL
Affinity DataIC50: 1.05E+3nMAssay Description:In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type A receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30E+3nMAssay Description:Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to rat pancreas Cholecystokinin type A receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-A receptor in the rat pancreasMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of [125I]-CCK-8 binding to Cholecystokinin type A receptor of rat pancreasMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of [125I]-CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.More data for this Ligand-Target Pair
Affinity DataIC50: 4.30E+3nMAssay Description:Compound measured for half-maximal inhibition of specific binding of [125I]-Bolton Hunter CCK-26-33 to CCK-A receptor in the rat pancreas.More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Compound measured for half-maximal inhibition of specific binding of [125I]-Bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.More data for this Ligand-Target Pair