BDBM50453052 CHEMBL4203378

SMILES CC(C)n1cc(NC(=O)c2ccc(Nc3cnc4ccccc4n3)cc2)c(=O)n(C(C)C(=O)N[C@H]2CC(=O)OC2O)c1=O

InChI Key InChIKey=ISJUYFBACBKWBV-HOTGVXAUSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50453052   

TargetCaspase-1(Homo sapiens (Human))
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453052(CHEMBL4203378)
Affinity DataIC50:  50nMAssay Description:Inhibition of caspase-1 in human THP1 cells assessed as decrease in LPS-induced IL-1beta secretion after overnight incubation by sandwich immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453052(CHEMBL4203378)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed