BDBM50455057 CHEMBL4215702::US10696678, Example 20
SMILES CN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc5CCC(C)(C)n5c4c3)nc2)CC1
InChI Key InChIKey=RFEGHSBZJMLRST-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50455057
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Beijing University Of Technology
Curated by ChEMBL
Beijing University Of Technology
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of CDK4 (unknown origin) after 90 mins by ADP-Glo assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1/G1/S-specific cyclin-D3(Homo sapiens (Human))
Beijing University Of Technology
Curated by ChEMBL
Beijing University Of Technology
Curated by ChEMBL
Affinity DataIC50: 354nMAssay Description:Inhibition of recombinant human full length CDK1/Cyclin D3 expressed in baculovirus infected Sf9 insect cells using histone H1 substrate after 90 min...More data for this Ligand-Target Pair
Affinity DataIC50: 354nMAssay Description:In vitro inhibition of CDK (CDK1, CDK4, CDK6) activity by compounds of the present invention was tested by the following method.1. Preparation of kin...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Homo sapiens (Human))
Gan & Lee Pharmaceuticals
US Patent
Gan & Lee Pharmaceuticals
US Patent
Affinity DataIC50: 800nMAssay Description:In vitro inhibition of CDK (CDK1, CDK4, CDK6) activity by compounds of the present invention was tested by the following method.1. Preparation of kin...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Gan & Lee Pharmaceuticals
US Patent
Gan & Lee Pharmaceuticals
US Patent
Affinity DataIC50: 4.00E+3nMAssay Description:In vitro inhibition of CDK (CDK1, CDK4, CDK6) activity by compounds of the present invention was tested by the following method.1. Preparation of kin...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Beijing University Of Technology
Curated by ChEMBL
Beijing University Of Technology
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human full length CDK6 expressed in baculovirus infected Sf9 insect cells using histone H1 substrate after 90 mins by ADP-G...More data for this Ligand-Target Pair