BDBM50457315 CHEMBL4210340::US10662187, Compound 105::US10793566, Compound 105

SMILES CC#CC(=O)N1CCC[C@H](C1)n1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2cnccc12

InChI Key InChIKey=GWSWYVDRDVOKTP-OAQYLSRUSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50457315   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50457315(CHEMBL4210340 | US10662187, Compound 105 | US10793...)
Affinity DataIC50:  100nMAssay Description:Inhibition of BTK (unknown origin) using peptide substrate after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50457315(CHEMBL4210340 | US10662187, Compound 105 | US10793...)
Affinity DataIC50:  550nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50457315(CHEMBL4210340 | US10662187, Compound 105 | US10793...)
Affinity DataIC50:  550nMAssay Description:Measurements were performed in a reaction volume of 15 μL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 μM peptide subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent