BDBM50469250 CHEMBL4281351

SMILES [H][C@@]12C[C@@]3([H])C[C@@](CNc4nc(NCc5ccccc5Br)ncc4C#N)(C1)C[C@@]([H])(C2)[C@H]3N

InChI Key InChIKey=MIWMFPOJJJMAJT-PTRWISQFSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50469250   

TargetProtein kinase C theta type(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50469250(CHEMBL4281351)
Affinity DataIC50:  31nMAssay Description:Inhibition of PKCtheta in human Jurkat cells transfected with pGL3-IL2 pro 43 plasmid assessed as suppression of IL-2 production after 14 hrs by fire...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50469250(CHEMBL4281351)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of recombinant full-length human PKCtheta using STK1-biotin as substrate preincubated for 60 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed