BDBM50499736 CHEMBL3740601

SMILES NC(=O)C[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(cc1)-c1ccccc1)C#N

InChI Key InChIKey=YWRRVZYQZWHQKZ-HKUYNNGSSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50499736   

TargetLegumain(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50499736(CHEMBL3740601)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-MCA substrate measured every 2 mins for 60 mins by microplate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50499736(CHEMBL3740601)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant cathepsin B (unknown origin) using Z-Leu-Arg-AMC fluorogenic substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50499736(CHEMBL3740601)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant caspase 3 (unknown origin) using DEVD-AFC fluorogenic substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50499736(CHEMBL3740601)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant cathepsin S (unknown origin) using ZVVR-AMC fluorogenic substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50499736(CHEMBL3740601)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant caspase 8 (unknown origin) using IETD-AFC fluorogenic substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 17(Homo sapiens)
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50499736(CHEMBL3740601)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of USP17 in human HEK293T cells using fluorogenic substrate ub-rhodamine110 preincubated for 30 mins followed by substrate addition measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed