BDBM50505988 CHEMBL4482864

SMILES COC[C@H]1Cn2cc(nc2C(=O)N1Cc1ccc(F)c(F)c1)-c1nc(Nc2ccnn2C)ncc1C

InChI Key InChIKey=HVIGNZUDBVLTLU-MRXNPFEDSA-N

Data  9 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50505988   

TargetCyclin-dependent kinase 5 activator 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505988(CHEMBL4482864)
Affinity DataIC50:  300nMAssay Description:Inhibition of recombinant full length human His-tagged CDK5/p35 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505988(CHEMBL4482864)
Affinity DataIC50:  0.660nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using ERKtide as substrate preincubated for 20 mins followed by substrate addition in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMitogen-activated protein kinase 1/3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505988(CHEMBL4482864)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of ERK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM50505988(CHEMBL4482864)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNUAK family SNF1-like kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505988(CHEMBL4482864)
Affinity DataIC50:  400nMAssay Description:Inhibition of recombinant full length human His-tagged ARK5 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50505988(CHEMBL4482864)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human full length C-terminal His6-tagged Cdk2/human full length N-terminal GST-tagged Cyclin E expressed in baculovirus infected Sf21 i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505988(CHEMBL4482864)
Affinity DataKd:  0.100nMAssay Description:Binding affinity to non-phosphorylated biotinylated ERK2 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMitogen-activated protein kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505988(CHEMBL4482864)
Affinity DataIC50: <0.300nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using ERKtide as substrate preincubated for 20 mins followed by substrate addition in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMitogen-activated protein kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505988(CHEMBL4482864)
Affinity DataKd:  0.0501nMAssay Description:Binding affinity to MEK-activated phosphorylated biotinylated ERK2 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMitogen-activated protein kinase 1/3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505988(CHEMBL4482864)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of RSK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCyclin-dependent kinase 5 activator 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505988(CHEMBL4482864)
Affinity DataIC50:  300nMAssay Description:Inhibition of recombinant full length human GST/His-tagged CDK5/p25 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed