BDBM50510991 CHEMBL4564735
SMILES NC1=N[C@@]2(CO1)c1cc(ccc1Oc1c(F)nc(cc21)C1=CCCOC1)-c1cccnc1F
InChI Key InChIKey=JAZOCUNZCUBRJX-DEOSSOPVSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50510991
Affinity DataIC50: 3nMAssay Description:Inhibition of BACE1 (unknown origin) using FRET peptide substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr by FRE...More data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Inhibition of BACE2 in mouse B16-F1 cells assessed as increase in intracellular PMEL17 Mbeta accumulation measured after 4 days by Western blot analy...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of BACE2 (unknown origin) using FRET peptide substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr by FRE...More data for this Ligand-Target Pair
Affinity DataIC50: 93nMAssay Description:Inhibition of recombinant CatD (unknown origin) expressed in CHO cells using FRET peptide substrate preincubated for 1 hr followed by substrate addit...More data for this Ligand-Target Pair
Affinity DataIC50: 75nMAssay Description:Inhibition of cathepsin E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of recombinant human BACE2 expressed in HEK293 cells co-transfected with N-terminal HA-tagged/C-terminal Myc tagged Mbeta chain of human P...More data for this Ligand-Target Pair