BDBM50529897 CHEMBL4468383

SMILES O[C@@H](CNC(=O)c1ccc2CN(CCc2c1)C(=O)c1ccc(Br)cc1)CN1CCc2ccccc2C1

InChI Key InChIKey=VFSOQQVDAIJQES-MHZLTWQESA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50529897   

TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant full length human N-terminal FLAG-tagged PRMT7 expressed in Sf9 insect cells preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 3(Homo sapiens)
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human N-terminal GST-tagged PRMT3 (2 to end residues) expressed in Escherichia coli preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant full length human N-terminal FLAG-tagged PRMT7 expressed in Sf9 insect cells preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human N-terminal His/FLAG-tagged PRMT8 (61 to 394 residues) expressed in baculovirus infected Sf9 insect cells preincubated for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 3(Homo sapiens)
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human N-terminal GST-tagged PRMT3 (2 to end residues) expressed in Escherichia coli preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human N-terminal GST-tagged PRMT1 (2 to end residues) expressed in baculovirus infected Sf9 insect cells preincubated for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human N-terminal GST-tagged PRMT1 (2 to end residues) expressed in baculovirus infected Sf9 insect cells preincubated for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 6(Homo sapiens (Human))
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human N-terminal His-tagged PRMT6 (2 to 375 residues) expressed in Escherichia coli preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 6(Homo sapiens (Human))
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human N-terminal His-tagged PRMT6 (2 to 375 residues) expressed in Escherichia coli preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human N-terminal His/FLAG-tagged PRMT8 (61 to 394 residues) expressed in baculovirus infected Sf9 insect cells preincubated for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human N-terminal FLAG-tagged PRMT4 (2 to end residues) expressed in FreeStyle 293-F cells preincubated for 15 mins followed by substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human N-terminal FLAG-tagged PRMT4 (2 to end residues) expressed in FreeStyle 293-F cells preincubated for 15 mins followed by substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed