BDBM50530394 CHEMBL4561663
SMILES NC(=O)c1ccccc1Nc1cc(Nc2ccc(F)cn2)ncc1C(N)=O
InChI Key InChIKey=HZNQENBILSFKNN-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 20 hits for monomerid = 50530394
Affinity DataKi: 0.0600nMAssay Description:Inhibition of TYK2 JH2 (unknown origin) by morrison titration assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.0600nMAssay Description:Inhibition of TYK2 JH2 (unknown origin) by morrison titration assayMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK2(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 89nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of JAK1/JAK3 (unknown origin) in IL-2 stimulated cells by cell based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.460nMAssay Description:Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mi...More data for this Ligand-Target Pair
Affinity DataEC50: 6.60nMAssay Description:Inhibition of TYK2 JH2 (unknown origin) by Scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.460nMAssay Description:Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 6.60nMAssay Description:Inhibition of TYK2 JH2 (unknown origin) by Scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK2(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 89nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of JAK1/JAK3 (unknown origin) in IL-2 stimulated cells by cell based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Inhibition of JAK1/JAK2 (unknown origin) in GM-CSF stimulated cells by cell based assayMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Inhibition of JAK1/JAK2 (unknown origin) in GM-CSF stimulated cells by cell based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair