BDBM50602864 CCS-1477::CCS1477::Ccs 1477::Ccs1477::INOBRODIB::Inobrodib

SMILES CO[C@H]1CC[C@@H](CC1)n1c(nc2cc(ccc12)-c1c(C)noc1C)[C@@H]1CCCC(=O)N1c1ccc(F)c(F)c1

InChI Key InChIKey=SKDNDJWEBPQKCS-CLHVYKLBSA-N

Data  1 IC50  7 Kd

PDB links: 5 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50602864   

TargetCREB-binding protein(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50602864(CCS-1477 | CCS1477 | Ccs 1477 | Ccs1477 | INOBRODI...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of His6-tagged human CBP bromodomain (1081 to 1197 residues) expressed in Escherichia coli BL21 (DE3) incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails PubMedPDB3D3D Structure (crystal)

TargetCREB-binding protein(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50602864(CCS-1477 | CCS1477 | Ccs 1477 | Ccs1477 | INOBRODI...)
Affinity DataKd:  14nMAssay Description:Binding affinity to His6-tagged human CBP bromodomain (1081 to 1197 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation const...More data for this Ligand-Target Pair
In DepthDetails PubMedPDB3D3D Structure (crystal)

TargetBromodomain-containing protein 9(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50602864(CCS-1477 | CCS1477 | Ccs 1477 | Ccs1477 | INOBRODI...)
Affinity DataKd:  2.61E+3nMAssay Description:Binding affinity to His6-tagged human BRD9 bromodomain (14 to 134 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constan...More data for this Ligand-Target Pair
In DepthDetails PubMed

TargetBromodomain testis-specific protein(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50602864(CCS-1477 | CCS1477 | Ccs 1477 | Ccs1477 | INOBRODI...)
Affinity DataKd:  1.12E+3nMAssay Description:Binding affinity to His6-tagged human BRDT bromodomain-1 (21 to 137 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation const...More data for this Ligand-Target Pair
In DepthDetails PubMed

TargetBromodomain-containing protein 3(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50602864(CCS-1477 | CCS1477 | Ccs 1477 | Ccs1477 | INOBRODI...)
Affinity DataKd:  560nMAssay Description:Binding affinity to His6-tagged human BRD3 bromodomain-1 (24 to 144 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation const...More data for this Ligand-Target Pair
In DepthDetails PubMed

TargetBromodomain-containing protein 3(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50602864(CCS-1477 | CCS1477 | Ccs 1477 | Ccs1477 | INOBRODI...)
Affinity DataKd:  1.51E+3nMAssay Description:Binding affinity to His6-tagged human BRD3 bromodomain-2 (306 to 416 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation cons...More data for this Ligand-Target Pair
In DepthDetails PubMed

TargetBromodomain-containing protein 4(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50602864(CCS-1477 | CCS1477 | Ccs 1477 | Ccs1477 | INOBRODI...)
Affinity DataKd:  360nMAssay Description:Binding affinity to His6-tagged human BRD4 bromodomain-1 (44 to 168 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation const...More data for this Ligand-Target Pair
In DepthDetails PubMedPDB3D3D Structure (crystal)

TargetBromodomain-containing protein 2(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50602864(CCS-1477 | CCS1477 | Ccs 1477 | Ccs1477 | INOBRODI...)
Affinity DataKd:  390nMAssay Description:Binding affinity to His6-tagged human BRD2 bromodomain-1 (77 to 194 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation const...More data for this Ligand-Target Pair
In DepthDetails PubMed