BDBM5470 6-methoxy-9H-purin-2-amine::CHEMBL226395::O6-Substituted Guanine Deriv. 1

SMILES COc1nc(N)nc2nc[nH]c12

InChI Key InChIKey=BXJHWYVXLGLDMZ-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 5470   

TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
University of Newcastle

LigandPNGBDBM5470(6-methoxy-9H-purin-2-amine | CHEMBL226395 | O6-Sub...)
Affinity DataAssay Description:The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2 [171-432]/Cyclin-dependent kinase 2(Homo sapiens (Human))
University of Newcastle

LigandPNGBDBM5470(6-methoxy-9H-purin-2-amine | CHEMBL226395 | O6-Sub...)
Affinity DataAssay Description:The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM5470(6-methoxy-9H-purin-2-amine | CHEMBL226395 | O6-Sub...)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro inhibitory concentration against angiotensin-converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM5470(6-methoxy-9H-purin-2-amine | CHEMBL226395 | O6-Sub...)
Affinity DataIC50:  4.28E+5nMAssay Description:Inhibition of AGT activity to 50% of control rate in HT-29 cell extractMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Institute Of Biological Chemistry And The Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM5470(6-methoxy-9H-purin-2-amine | CHEMBL226395 | O6-Sub...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human xanthine oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM5470(6-methoxy-9H-purin-2-amine | CHEMBL226395 | O6-Sub...)
Affinity DataIC50:  2.48E+5nMAssay Description:concentration required to reduce AGT activity to 50% of control rate in intact HT-29 human colorectal carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed