BDBM54705 CHEMBL1297::Fenoprofen::UNM-0000306101::calcium;2-(3-phenoxyphenyl)propanoic acid;hydrate::calcium;2-(3-phenoxyphenyl)propionic acid;hydrate::cid_16219353

SMILES CC(C(O)=O)c1cccc(Oc2ccccc2)c1

InChI Key InChIKey=RDJGLLICXDHJDY-UHFFFAOYSA-N

Data  8 KI  2 IC50  8 EC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 54705   

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Dallas Department Of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM54705(CHEMBL1297 | Fenoprofen | UNM-0000306101 | calcium...)
Affinity DataKi:  2.73E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Dallas Department Of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM54705(CHEMBL1297 | Fenoprofen | UNM-0000306101 | calcium...)
Affinity DataKi:  3.40E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM54705(CHEMBL1297 | Fenoprofen | UNM-0000306101 | calcium...)
Affinity DataKi:  5.90E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM54705(CHEMBL1297 | Fenoprofen | UNM-0000306101 | calcium...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM54705(CHEMBL1297 | Fenoprofen | UNM-0000306101 | calcium...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetLactoylglutathione lyase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM54705(CHEMBL1297 | Fenoprofen | UNM-0000306101 | calcium...)
Affinity DataKi:  3.83E+5nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM54705(CHEMBL1297 | Fenoprofen | UNM-0000306101 | calcium...)
Affinity DataKi:  3.83E+5nMAssay Description:Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM54705(CHEMBL1297 | Fenoprofen | UNM-0000306101 | calcium...)
Affinity DataKi:  4.00E+5nMAssay Description:Inhibition of glyoxalase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM54705(CHEMBL1297 | Fenoprofen | UNM-0000306101 | calcium...)
Affinity DataIC50:  2.73E+3nMAssay Description:Inhibition of ovine COX1 assessed as reduction in PGH2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM54705(CHEMBL1297 | Fenoprofen | UNM-0000306101 | calcium...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
LigandPNGBDBM54705(CHEMBL1297 | Fenoprofen | UNM-0000306101 | calcium...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetGTPase KRas [1-37](Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM54705(CHEMBL1297 | Fenoprofen | UNM-0000306101 | calcium...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetRas-related protein Rab-7a(Canis lupus familiaris)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM54705(CHEMBL1297 | Fenoprofen | UNM-0000306101 | calcium...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM54705(CHEMBL1297 | Fenoprofen | UNM-0000306101 | calcium...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM54705(CHEMBL1297 | Fenoprofen | UNM-0000306101 | calcium...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM54705(CHEMBL1297 | Fenoprofen | UNM-0000306101 | calcium...)
Affinity DataIC50:  2.63E+4nMAssay Description:Inhibition of ovine COX2 assessed as reduction in PGH2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase KRas [1-37](Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM54705(CHEMBL1297 | Fenoprofen | UNM-0000306101 | calcium...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetRas-related protein Rab-2A(Canis lupus familiaris)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM54705(CHEMBL1297 | Fenoprofen | UNM-0000306101 | calcium...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay