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BDBM5566 2,6-Diamino-4-cyclohexylmethoxy-5-nitrosopyrimidine::6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine::NU6027::pyrimidine deriv.

SMILES: Nc1nc(N)c(N=O)c(OCC2CCCCC2)n1

InChI Key: InChIKey=DGWXOLHKVGDQLN-UHFFFAOYSA-N

Data: 4 KI  6 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 5566   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-dependent kinase 2


(Homo sapiens (human))
BDBM5566
PNG
(2,6-Diamino-4-cyclohexylmethoxy-5-nitrosopyrimidin...)
Show SMILES Nc1nc(N)c(N=O)c(OCC2CCCCC2)n1
Show InChI InChI=1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15)
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Article
PubMed
1.30E+3n/an/an/an/an/an/an/an/a



Instituto Universitario de Bio-Org£nica Antonio Gonz£lez (IUBO-AG)

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 21: 6641-5 (2011)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclin-Dependent Kinase 2 (CDK2)


(Homo sapiens (human))
BDBM5566
PNG
(2,6-Diamino-4-cyclohexylmethoxy-5-nitrosopyrimidin...)
Show SMILES Nc1nc(N)c(N=O)c(OCC2CCCCC2)n1
Show InChI InChI=1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15)
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PubMed
1.30E+3 -8.16n/an/an/an/an/a7.530



University of Newcastle



Assay Description
The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...


J Med Chem 43: 2797-804 (2000)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM5566
PNG
(2,6-Diamino-4-cyclohexylmethoxy-5-nitrosopyrimidin...)
Show SMILES Nc1nc(N)c(N=O)c(OCC2CCCCC2)n1
Show InChI InChI=1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15)
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PubMed
2.50E+3 -7.77n/an/an/an/an/a7.530



University of Newcastle



Assay Description
The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...


J Med Chem 43: 2797-804 (2000)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 1


(Homo sapiens (human))
BDBM5566
PNG
(2,6-Diamino-4-cyclohexylmethoxy-5-nitrosopyrimidin...)
Show SMILES Nc1nc(N)c(N=O)c(OCC2CCCCC2)n1
Show InChI InChI=1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15)
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PubMed
2.50E+3n/an/an/an/an/an/an/an/a



Instituto Universitario de Bio-Org£nica Antonio Gonz£lez (IUBO-AG)

Curated by ChEMBL


Assay Description
Inhibition of CDK1


Bioorg Med Chem Lett 21: 6641-5 (2011)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM5566
PNG
(2,6-Diamino-4-cyclohexylmethoxy-5-nitrosopyrimidin...)
Show SMILES Nc1nc(N)c(N=O)c(OCC2CCCCC2)n1
Show InChI InChI=1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15)
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PubMed
n/an/a 6.70E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of flag-tagged ATR expressed in HEK293T cells using PHAS-1 as substrate after 20 mins by autoradiography


Bioorg Med Chem Lett 22: 5352-9 (2012)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 2 (CDK2)


(Homo sapiens (human))
BDBM5566
PNG
(2,6-Diamino-4-cyclohexylmethoxy-5-nitrosopyrimidin...)
Show SMILES Nc1nc(N)c(N=O)c(OCC2CCCCC2)n1
Show InChI InChI=1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15)
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Article
PubMed
n/an/a 2.20E+3n/an/an/an/a7.530



University of Newcastle



Assay Description
The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...


Bioorg Med Chem Lett 13: 3079-82 (2003)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (human))
BDBM5566
PNG
(2,6-Diamino-4-cyclohexylmethoxy-5-nitrosopyrimidin...)
Show SMILES Nc1nc(N)c(N=O)c(OCC2CCCCC2)n1
Show InChI InChI=1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15)
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Article
PubMed
n/an/a 2.90E+3n/an/an/an/an/an/a



Universit£ degli Studi di Torino

Curated by ChEMBL


Assay Description
Inhibition of CDK1/Cyclin B (unknown origin)


Eur J Med Chem 68: 333-8 (2013)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 2 (CDK2)


(Homo sapiens (human))
BDBM5566
PNG
(2,6-Diamino-4-cyclohexylmethoxy-5-nitrosopyrimidin...)
Show SMILES Nc1nc(N)c(N=O)c(OCC2CCCCC2)n1
Show InChI InChI=1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15)
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NCI pathway
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Article
PubMed
n/an/a 2.20E+3n/an/an/an/a7.530



University of Newcastle



Assay Description
The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...


J Med Chem 43: 2797-804 (2000)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM5566
PNG
(2,6-Diamino-4-cyclohexylmethoxy-5-nitrosopyrimidin...)
Show SMILES Nc1nc(N)c(N=O)c(OCC2CCCCC2)n1
Show InChI InChI=1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15)
UniProtKB/SwissProt

GoogleScholar
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Purchase

DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

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Article
PubMed
n/an/a 2.90E+3n/an/an/an/a7.530



University of Newcastle



Assay Description
The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...


J Med Chem 43: 2797-804 (2000)

More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM5566
PNG
(2,6-Diamino-4-cyclohexylmethoxy-5-nitrosopyrimidin...)
Show SMILES Nc1nc(N)c(N=O)c(OCC2CCCCC2)n1
Show InChI InChI=1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.90E+3n/an/an/an/a7.530



University of Newcastle



Assay Description
The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...


Bioorg Med Chem Lett 13: 3079-82 (2003)

More data for this
Ligand-Target Pair