BDBM5777 4-butoxy-5-[(4-chloro-2,6-difluorophenyl)carbonyl]-1H-pyrazolo[3,4-b]pyridine::SQ-67563 Analog 21i::pyrazolo[3,4-b]pyridine deriv.

SMILES CCCCOc1c(cnc2[nH]ncc12)C(=O)c1c(F)cc(Cl)cc1F

InChI Key InChIKey=KHLSGMMGWBAAOY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 5777   

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM5777(4-butoxy-5-[(4-chloro-2,6-difluorophenyl)carbonyl]...)
Affinity DataIC50:  13nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM5777(4-butoxy-5-[(4-chloro-2,6-difluorophenyl)carbonyl]...)
Affinity DataIC50:  310nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM5777(4-butoxy-5-[(4-chloro-2,6-difluorophenyl)carbonyl]...)
Affinity DataIC50:  27nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed